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KMID : 1188320110050020217
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Gut and Liver
2011 Volume.5 No. 2 p.217 ~ p.220
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The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea
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Cho Hyun-Chin
Kim Yu-Jin
Choi Moon-Seok
Lee Joon-Hyeok
Koh Kwang-Cheol
Yoo Byung-Chul
Paik Seung-Woon
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Abstract
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Background/Aims: The aim of this study was to evaluate the seroconversion rate of a hepatitis A virus (HAV) vaccination in patients with hepatitis B virus (HBV)-related chronic liver disease (CLD).
Methods: Analyses were conducted using clinical records from 94 patients with chronic HBV infection who were seronegative for IgG anti-HAV antibodies between September 2008 and June 2009. Two doses of an HAV vaccine were administered 24 weeks apart. A third vaccine dose was administered only for patients seronegative for anti-HAV antibodies at week 48.
Results: The seroconversion rate of anti-HAV following the two-dose vaccination was 86.17%. The seroconversion rate of anti-HAV was not signifi cantly different according to age or status of liver disease. The rate was higher in female than in male patients. A third HAV vaccine dose was administered to 13 patients seronegative for anti-HAV after the two-dose regimen, and 84.62% of these patients showed seroconversion at week 72.
Conclusions: HAV vaccination is effective in most Korean patients with HBV-related CLD, and it might be necessary to evaluate three-dose vaccination approach for non-responders to the conventional regimen to maximize the success of an HAV vaccination program.
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KEYWORD
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Chronic hepatitis B, Hepatitis B virus related liver cirrhosis, Hepatitis A virus vaccination
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